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An Efficient Solution-Phase Synthesis of 4,5,7-Trisubstituted Pyrrolo[3,2-d]pyrimidines
[Image: see text] We have developed an efficient and robust route to synthesize 4,5,7-trisubstituted pyrrolo[3,2-d]pyrimidines as potent kinase inhibitors. This solution-phase synthesis features a S(N)Ar substitution reaction, cross-coupling reaction, one-pot reduction/reductive amination and N-alky...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3724770/ https://ncbi.nlm.nih.gov/pubmed/23181516 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/co300106f |
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