Leucine-rich Repeat and Immunoglobulin Domain-containing Protein-1 (Lrig1) Negative Regulatory Action toward ErbB Receptor Tyrosine Kinases Is Opposed by Leucine-rich Repeat and Immunoglobulin Domain-containing Protein 3 (Lrig3)

Lrig1 is the founding member of the Lrig family of transmembrane leucine-rich repeat proteins, which also includes Lrig2 and Lrig3. Lrig1 is a negative regulator of oncogenic receptor tyrosine kinases, including ErbB and Met receptors, and promotes receptor degradation. Lrig1 has recently emerged as...

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Detalhes bibliográficos
Main Authors: Rafidi, Hanine, Mercado, Francisco, Astudillo, Michael, Fry, William H. D., Saldana, Matthew, Carraway, Kermit L., Sweeney, Colleen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3724619/
https://ncbi.nlm.nih.gov/pubmed/23723069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.486050
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