A Gain-of-Function Mutation in the M-domain of Cardiac Myosin-binding Protein-C Increases Binding to Actin

The M-domain is the major regulatory subunit of cardiac myosin-binding protein-C (cMyBP-C) that modulates actin and myosin interactions to influence muscle contraction. However, the precise mechanism(s) and the specific residues involved in mediating the functional effects of the M-domain are not fu...

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Detalhes bibliográficos
Main Authors: Bezold, Kristina L., Shaffer, Justin F., Khosa, Jaskiran K., Hoye, Elaine R., Harris, Samantha P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3724610/
https://ncbi.nlm.nih.gov/pubmed/23782699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.474346
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