Distinctive Changes in Plasma Membrane Phosphoinositides Underlie Differential Regulation of TRPV1 in Nociceptive Neurons

Transient Receptor Potential Vanilloid 1 (TRPV1) is a polymodal, Ca(2+)-permeable cation channel crucial to regulation of nociceptor responsiveness. Sensitization of TRPV1 by G-protein coupled receptor (GPCR) agonists to its endogenous activators, such as low pH and noxious heat, is a key factor in...

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Bibliographic Details
Main Authors: Lukacs, Viktor, Yudin, Yevgen, Hammond, Gerald R., Sharma, Esseim, Fukami, Kiyoko, Rohacs, Tibor
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3724548/
https://ncbi.nlm.nih.gov/pubmed/23843517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5637-12.2013
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