Improvement of aortic valve stenosis by ApoA-I mimetic therapy is associated with decreased aortic root and valve remodelling in mice

BACKGROUND AND PURPOSE: We have shown that infusions of apolipoprotein A-I (ApoA-I) mimetic peptide induced regression of aortic valve stenosis (AVS) in rabbits. This study aimed at determining the effects of ApoA-I mimetic therapy in mice with calcific or fibrotic AVS. EXPERIMENTAL APPROACH: Apolip...

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Главные авторы: Trapeaux, J, Busseuil, D, Shi, Y, Nobari, S, Shustik, D, Mecteau, M, El-Hamamsy, I, Lebel, M, Mongrain, R, Rhéaume, E, Tardif, J-C
Формат: Artigo
Язык:Inglês
Опубликовано: Blackwell Publishing Ltd 2013
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Research Papers
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3724114/
https://ncbi.nlm.nih.gov/pubmed/23638718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12236
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