Attenuation of TNF production and experimentally induced inflammation by PDE4 inhibitor rolipram is mediated by MAPK phosphatase-1

BACKGROUND AND PURPOSE: 3′,5′-Cyclic nucleotide PDE4 is expressed in several inflammatory and immune cells, and PDE4 catalyses the hydrolysis of cAMP to 5′AMP, down-regulating cAMP signalling in cells. MAPK phosphatase-1 (MKP-1) is an endogenous p38 MAPK signalling suppressor and limits inflammatory...

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Bibliographic Details
Main Authors: Korhonen, Riku, Hömmö, Tuija, Keränen, Tiina, Laavola, Mirka, Hämäläinen, Mari, Vuolteenaho, Katriina, Lehtimäki, Lauri, Kankaanranta, Hannu, Moilanen, Eeva
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2013
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3724109/
https://ncbi.nlm.nih.gov/pubmed/23849041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12189
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