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Glycogen Phosphorylase Inhibitor N-(3,5-Dimethyl-Benzoyl)-N’-(β-D-Glucopyranosyl)Urea Improves Glucose Tolerance under Normoglycemic and Diabetic Conditions and Rearranges Hepatic Metabolism
Glycogen phosphorylase (GP) catalyzes the breakdown of glycogen and largely contributes to hepatic glucose production making GP inhibition an attractive target to modulate glucose levels in diabetes. Hereby we present the metabolic effects of a novel, potent, glucose-based GP inhibitor (KB228) teste...
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主要な著者: | , , , , , , , , , , |
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フォーマット: | Artigo |
言語: | Inglês |
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Public Library of Science
2013
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3723905/ https://ncbi.nlm.nih.gov/pubmed/23936011 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069420 |
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