The Peripheral Myeloid Expansion Driven by Murine Cancer Progression Is Reversed by Radiation Therapy of the Tumor

Expansion of myeloid-lineage leukocytes in tumor-bearing mice has been proposed as a cause of systemic immunosuppression. We demonstrate that radiation therapy of tumors leads to a decline in myeloid cell numbers in the blood and a decrease in spleen size. The frequency of myeloid cells does not dec...

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Bibliographic Details
Main Authors: Crittenden, Marka R., Savage, Talicia, Cottam, Benjamin, Bahjat, Keith S., Redmond, William L., Bambina, Shelly, Kasiewicz, Melissa, Newell, Pippa, Jackson, Andrew M., Gough, Michael J.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3723876/
https://ncbi.nlm.nih.gov/pubmed/23936036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069527
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