Deep brain stimulation modulates nonsense-mediated RNA decay in Parkinson’s patients leukocytes

BACKGROUND: Nonsense-Mediated decay (NMD) selectively degrades mRNA transcripts that carry premature stop codons. NMD is often triggered by alternative splicing (AS) modifications introducing such codons. NMD plays an important regulatory role in brain neurons, but the in vivo dynamics of AS and NMD...

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Hauptverfasser: Soreq, Lilach, Bergman, Hagai, Israel, Zvi, Soreq, Hermona
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3723527/
https://ncbi.nlm.nih.gov/pubmed/23865419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-14-478
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