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Cyanoacetamide MCR (III): Three-Component Gewald Reactions Revisited

Cyanoacetic acid derivatives are the starting materials for a plethora of multicomponent reaction (MCR) scaffolds. Here we describe valuable general protocols for the synthesis of arrays of 2-aminothiophene-3-carboxamides from cyanoacetamides, aldehydes or ketones and sulfur via a Gewald-3CR variati...

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Autors principals: Wang, Kan, Kim, Dabin, Dömling, Alexander
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3721980/
https://ncbi.nlm.nih.gov/pubmed/19958011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cc9001586
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