Nkx2-1 Represses a Latent Gastric Differentiation Program in Lung Adenocarcinoma

Tissue-specific differentiation programs become dysregulated during cancer evolution. The transcription factor Nkx2-1 is a master regulator of pulmonary differentiation that is downregulated in poorly differentiated lung adenocarcinoma. Here we use conditional murine genetics to determine how the id...

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Autori principali: Snyder, Eric L., Watanabe, Hideo, Magendantz, Margaret, Hoersch, Sebastian, Chen, Tiffany A., Wang, Diana G., Crowley, Denise, Whittaker, Charles A., Meyerson, Matthew, Kimura, Shioko, Jacks, Tyler
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3721642/
https://ncbi.nlm.nih.gov/pubmed/23523371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.02.018
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