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Genotoxicity of pemetrexed in human peripheral blood lymphocytes

Pemetrexed (PMX) is an antineoplastic antifolate used in the treatment of non-small cell lung cancer, mesothelioma and several types of neoplasms. Its toxicity in tumor cells has been linked with the potent inhibition of thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide fo...

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Detalhes bibliográficos
Main Authors: İstifli, Erman Salih, Topaktaş, Mehmet
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Netherlands 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3720975/
https://ncbi.nlm.nih.gov/pubmed/23179091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10616-012-9516-4
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