Standard Pentostatin Dose Reductions in Renal Insufficiency are not Adequate: Selected Patients with Steroid-Refractory Acute Graft-versus-Host Disease

BACKGROUND AND OBJECTIVE: Pentostatin is an irreversible inhibitor of adenosine deaminase and has been used to prevent graft-versus-host disease (GVHD) and to treat both acute and chronic GVHD. Dose reduction equations for patients with renal insufficiency are based on few patients with limited phar...

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Main Authors: Poi, Ming J., Hofmeister, Craig C., Johnston, Jeffrey S., Edwards, Ryan B., Jansak, Buffy S., Lucas, David M., Farag, Sherif S., Dalton, James T., Devine, Steven M., Grever, Michael R., Phelps, Mitch A.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3720841/
https://ncbi.nlm.nih.gov/pubmed/23588536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-013-0064-7
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