Melittin Suppresses HIF-1α/VEGF Expression through Inhibition of ERK and mTOR/p70S6K Pathway in Human Cervical Carcinoma Cells

OBJECTIVE: Melittin (MEL), a major component of bee venom, has been associated with various diseases including arthritis, rheumatism and various cancers. In this study, the anti-angiogenic effects of MEL in CaSki cells that were responsive to the epidermal growth factor (EGF) were examined. METHODOL...

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Detalhes bibliográficos
Main Authors: Shin, Jae-Moon, Jeong, Yun-Jeong, Cho, Hyun-Ji, Park, Kwan-Kyu, Chung, Il-Kyung, Lee, In-Kyu, Kwak, Jong-Young, Chang, Hyeun-Wook, Kim, Cheorl-Ho, Moon, Sung-Kwon, Kim, Wun-Jae, Choi, Yung-Hyun, Chang, Young-Chae
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3720276/
https://ncbi.nlm.nih.gov/pubmed/23936001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069380
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