A Transgenic Alzheimer Rat with Plaques, Tau Pathology, Behavioral Impairment, Oligomeric Aβ, and Frank Neuronal Loss

Alzheimer's disease (AD) is hallmarked by amyloid plaques, neurofibrillary tangles, and widespread cortical neuronal loss (Selkoe, 2001). The “amyloid cascade hypothesis” posits that cerebral amyloid sets neurotoxic events into motion that precipitate Alzheimer dementia (Hardy and Allsop, 1991)...

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Main Authors: Cohen, Robert M., Rezai-Zadeh, Kavon, Weitz, Tara M., Rentsendorj, Altan, Gate, David, Spivak, Inna, Bholat, Yasmin, Vasilevko, Vitaly, Glabe, Charles G., Breunig, Joshua J., Rakic, Pasko, Davtyan, Hayk, Agadjanyan, Michael G., Kepe, Vladimir, Barrio, Jorge R., Bannykh, Serguei, Szekely, Christine A., Pechnick, Robert N., Town, Terrence
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3720142/
https://ncbi.nlm.nih.gov/pubmed/23575824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3672-12.2013
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