Clinical and Genetic Determinants of Plasma Nevirapine Exposure Following an Intrapartum Dose to Prevent Mother-to-Child HIV Transmission

Objective. Nevirapine is metabolized by cytochrome P450 (CYP) 2B6 and CYP3A4. We characterized relationships between clinical parameters, human genetics, pharmacokinetics, and human immunodeficiency virus type 1 (HIV-1) drug resistance mutations in pregnant women following single-dose intrapartum ne...

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Hlavní autoři: Vardhanabhuti, Saran, Acosta, Edward P., Ribaudo, Heather J., Severe, Patrice, Lalloo, Umesh, Kumarasamy, Nagalingeshwaran, Taulo, Frank, Kabanda, Joseph, Oneko, Olola, Ive, Prudence, Sambarey, Pradeep, Chan, Ellen S., Hitti, Jane, Hong, Francis, McMahon, Deborah, Haas, David W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
Témata:
Major Articles and Brief Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719905/
https://ncbi.nlm.nih.gov/pubmed/23687222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jit223
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