Relationship Between Weight, Efavirenz Exposure, and Virologic Suppression in HIV-Infected Patients on Rifampin-Based Tuberculosis Treatment in the AIDS Clinical Trials Group A5221 STRIDE Study

Background. Rifampin (RIF) upregulates CYP 450 isoenzymes, potentially lowering efavirenz (EFV) exposure. The US EFV package insert recommends an EFV dose increase for patients on RIF weighing ≥50 kg. We conducted a pharmacokinetic study to evaluate EFV trough concentrations (C(min)) and human immun...

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Detalhes bibliográficos
Main Authors: Luetkemeyer, Anne F., Rosenkranz, Susan L., Lu, Darlene, Marzan, Florence, Ive, Prudence, Hogg, Evelyn, Swindells, Susan, Benson, Constance A., Grinsztejn, Beatriz, Sanne, Ian M., Havlir, Diane V., Aweeka, Francesca
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
HIV/AIDS
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719885/
https://ncbi.nlm.nih.gov/pubmed/23592830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/cit246
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