Role of the Phosphatidylserine Receptor TIM-1 in Enveloped-Virus Entry

The cell surface receptor T cell immunoglobulin mucin domain 1 (TIM-1) dramatically enhances filovirus infection of epithelial cells. Here, we showed that key phosphatidylserine (PtdSer) binding residues of the TIM-1 IgV domain are critical for Ebola virus (EBOV) entry through direct interaction wit...

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Bibliographic Details
Main Authors: Moller-Tank, Sven, Kondratowicz, Andrew S., Davey, Robert A., Rennert, Paul D., Maury, Wendy
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2013
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719829/
https://ncbi.nlm.nih.gov/pubmed/23698310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01025-13
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