Antibiotic Trapping by Plasmid-Encoded CMY-2 β-Lactamase Combined with Reduced Outer Membrane Permeability as a Mechanism of Carbapenem Resistance in Escherichia coli

A liver transplant patient was admitted with cholangitis, for which meropenem therapy was started. Initial cultures showed a carbapenem-susceptible (CS) Escherichia coli strain, but during admission, a carbapenem-resistant (CR) E. coli strain was isolated. Analysis of the outer membrane protein prof...

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Главные авторы: Goessens, Wil H. F., van der Bij, Akke K., van Boxtel, Ria, Pitout, Johann D. D., van Ulsen, Peter, Melles, Damian C., Tommassen, Jan
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2013
Предметы:
Mechanisms of Resistance
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719783/
https://ncbi.nlm.nih.gov/pubmed/23733461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02459-12
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