The Keap1-Nrf2 System Prevents Onset of Diabetes Mellitus

Transcription factor Nrf2 (NF-E2-related factor 2) regulates a broad cytoprotective response to environmental stresses. Keap1 (Kelch-like ECH-associated protein 1) is an adaptor protein for cullin3-based ubiquitin E3 ligase and negatively regulates Nrf2. Whereas the Keap1-Nrf2 system plays important...

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Main Authors: Uruno, Akira, Furusawa, Yuki, Yagishita, Yoko, Fukutomi, Toshiaki, Muramatsu, Hiroyuki, Negishi, Takaaki, Sugawara, Akira, Kensler, Thomas W., Yamamoto, Masayuki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719683/
https://ncbi.nlm.nih.gov/pubmed/23716596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00225-13
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