Structural Analysis of Rev-erbα Bound to NCoR Reveals a Unique Mechanism of Nuclear Receptor-Corepressor Interaction

Repression by the nuclear receptor (NR) Rev-erbα plays an integral role in the core molecular circadian clock. We report the crystal structure of a Nuclear Receptor Corepressor (NCoR) Interaction Domain 1 (ID1) peptide bound to truncated human Rev-erbα ligand binding domain (LBD). The ID1 peptide fo...

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Detalhes bibliográficos
Main Authors: Phelan, Caroline A., Gampe, Robert T., Lambert, Millard H., Parks, Derek J., Montana, Valerie, Bynum, Jane, Broderick, Timothy M., Hu, Xiao, Williams, Shawn P., Nolte, Robert T., Lazar, Mitchell A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719173/
https://ncbi.nlm.nih.gov/pubmed/20581824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1860
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