Structural Analysis of Rev-erbα Bound to NCoR Reveals a Unique Mechanism of Nuclear Receptor-Corepressor Interaction

Repression by the nuclear receptor (NR) Rev-erbα plays an integral role in the core molecular circadian clock. We report the crystal structure of a Nuclear Receptor Corepressor (NCoR) Interaction Domain 1 (ID1) peptide bound to truncated human Rev-erbα ligand binding domain (LBD). The ID1 peptide fo...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Phelan, Caroline A., Gampe, Robert T., Lambert, Millard H., Parks, Derek J., Montana, Valerie, Bynum, Jane, Broderick, Timothy M., Hu, Xiao, Williams, Shawn P., Nolte, Robert T., Lazar, Mitchell A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719173/
https://ncbi.nlm.nih.gov/pubmed/20581824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1860
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares