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MULTISCALE MOLECULAR MODELING AND RATIONAL DESIGN OF POLYMER BASED GENE DELIVERY VECTORS
We used multiscale modeling technique and investigated several issues in non-viral based gene delivery using polyethyelenimine (PEI). Atomistic molecular dynamic simulations captured the spontaneous complex formation between a short PEI chain and a poly-(L) lysine (PLL) chain with DNA helices. Atomi...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3718391/ https://ncbi.nlm.nih.gov/pubmed/22195833 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2011.08.072 |
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