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Massively parallel in vivo enhancer assay reveals that highly local features determine the cis-regulatory function of ChIP-seq peaks

Transcription factors (TFs) recognize short sequence motifs that are present in millions of copies in large eukaryotic genomes. TFsmust distinguish their target binding sites from a vast genomic excess of spurious motif occurrences; however, it is unclear whether functional sites are distinguished f...

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Main Authors: White, Michael A., Myers, Connie A., Corbo, Joseph C., Cohen, Barak A.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3718143/
https://ncbi.nlm.nih.gov/pubmed/23818646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1307449110
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