NMDA Receptor Blockade by Ketamine Abrogates Lipopolysaccharide-Induced Depressive-Like Behavior in C57BL/6J Mice

We have previously demonstrated that lipopolysaccharide (LPS) induces depressive-like behavior by activating indoleamine 2,3 dioxygenase (IDO; O'Connor et al, 2009c). IDO degrades tryptophan along the kynurenine pathway. Using mass-spectrometry (LC-MS) analysis of kynurenine metabolites in the...

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Главные авторы: Walker, Adam K, Budac, David P, Bisulco, Stephanie, Lee, Anna W, Smith, Robin A, Beenders, Brent, Kelley, Keith W, Dantzer, Robert
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2013
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3717543/
https://ncbi.nlm.nih.gov/pubmed/23511700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2013.71
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