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Genome evolution predicts genetic interactions in protein complexes and reveals cancer drug targets
Genetic interactions reveal insights into cellular function and can be used to identify drug targets. Here we construct a new model to predict negative genetic interactions in protein complexes by exploiting the evolutionary history of genes in parallel converging pathways in metabolism. We evaluate...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Pub. Group
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3717498/ https://ncbi.nlm.nih.gov/pubmed/23851603 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3124 |
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