Disulfide reduction converts the insulin receptor of human placenta to a low affinity form.
Treatment of human placenta membranes with dithiothrietol (DTT) followed by N-ethylmaleimide results in a 60% reduction in insulin binding. Treatment with N-ethylmaleimide alone has little effect. The decrease in insulin binding that results from DTT treatment is due to a decrease in affinity for in...
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| Published in: | J Clin Invest |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Clinical Investigation
1980
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC371629/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7440724/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI109996 |
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