A Cyclic Peptide Inhibitor of HIF-1 Heterodimerization That Inhibits Hypoxia Signaling in Cancer Cells

[Image: see text] Hypoxia inducible factor-1 (HIF-1) is a heterodimeric transcription factor that acts as the master regulator of cellular response to reduced oxygen levels, thus playing a key role in the adaptation, survival, and progression of tumors. Here we report cyclo-CLLFVY, identified from a...

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Autori principali: Miranda, Elena, Nordgren, Ida K., Male, Abigail L., Lawrence, Charlotte E., Hoakwie, Franciane, Cuda, Francesco, Court, William, Fox, Keith R., Townsend, Paul A., Packham, Graham K., Eccles, Suzanne A., Tavassoli, Ali
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2013
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3715890/
https://ncbi.nlm.nih.gov/pubmed/23796364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja402993u
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