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R-loops and nicks initiate DNA breakage and genome instability in non-growing Escherichia coli
Double-stranded DNA ends, often from replication, drive genomic instability, yet their origin in non-replicating cells is unknown. Here we show that transcriptional RNA/DNA hybrids (R-loops) generate DNA ends that underlie stress-induced mutation and amplification. Depleting RNA/DNA hybrids with ove...
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| 主要な著者: | , , , , , |
|---|---|
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Pub. Group
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3715873/ https://ncbi.nlm.nih.gov/pubmed/23828459 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3115 |
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