Wnt/β-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours

We show that activation of Wnt/β-catenin and attenuation of Bmp signals, by combined gain- and loss-of-function mutations of β-catenin and Bmpr1a, respectively, results in rapidly growing, aggressive squamous cell carcinomas (SCC) in the salivary glands of mice. Tumours contain transplantable and hy...

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Main Authors: Wend, Peter, Fang, Liang, Zhu, Qionghua, Schipper, Jörg H, Loddenkemper, Christoph, Kosel, Frauke, Brinkmann, Volker, Eckert, Klaus, Hindersin, Simone, Holland, Jane D, Lehr, Stephan, Kahn, Michael, Ziebold, Ulrike, Birchmeier, Walter
Formato: Artigo
Idioma:Inglês
Publicado: European Molecular Biology Organization 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3715856/
https://ncbi.nlm.nih.gov/pubmed/23736260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.127
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