Full-Length Recombinant Plasmodium falciparum VAR2CSA Binds Specifically to CSPG and Induces Potent Parasite Adhesion-Blocking Antibodies

Plasmodium falciparum malaria remains one of the world's leading causes of human suffering and poverty. Each year, the disease takes 1–3 million lives, mainly in sub-Saharan Africa. The adhesion of infected erythrocytes (IEs) to vascular endothelium or placenta is the key event in the pathogene...

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Auteurs principaux: Khunrae, Pongsak, Dahlbäck, Madeleine, Nielsen, Morten A., Andersen, Gorm, Ditlev, Sisse B., Resende, Mafalda, Pinto, Vera V., Theander, Thor G., Higgins, Matthew K., Salanti, Ali
Format: Artigo
Langue:Inglês
Publié: Elsevier 2010
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3715698/
https://ncbi.nlm.nih.gov/pubmed/20109466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.01.040
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