Activation of CRH receptor type 1 expressed on glutamatergic neurons increases excitability of CA1 pyramidal neurons by the modulation of voltage-gated ion channels

Corticotropin-releasing hormone (CRH) plays an important role in a substantial number of patients with stress-related mental disorders, such as anxiety disorders and depression. CRH has been shown to increase neuronal excitability in the hippocampus, but the underlying mechanisms are poorly understo...

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Autors principals: Kratzer, Stephan, Mattusch, Corinna, Metzger, Michael W., Dedic, Nina, Noll-Hussong, Michael, Kafitz, Karl W., Eder, Matthias, Deussing, Jan M., Holsboer, Florian, Kochs, Eberhard, Rammes, Gerhard
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2013
Matèries:
Neuroscience
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3715697/
https://ncbi.nlm.nih.gov/pubmed/23882180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2013.00091
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