A 72-week randomized study of the safety and efficacy of a d4T to AZT switch at 24 weeks compared to AZT or TDF when given with 3TC and NVP

BACKGROUND: Due to superior long-term toxicity profile, AZT and TDF are preferred to d4T for first-line antiretroviral regimens. However, short-term d4T use could be beneficial in avoiding AZT-induced anemia. METHODS: We randomized (1:1:1) 150 treatment-naive Thai HIV-infected adults with CD4 count...

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Główni autorzy: Phanuphak, Nittaya, Ananworanich, Jintanat, Teeratakulpisarn, Nipat, Jadwattanakul, Tanate, Kerr, Stephen J., Chomchey, Nitiya, Hongchookiat, Piranun, Mathajittiphun, Pornpen, Pinyakorn, Suteeraporn, Rungrojrat, Patcharawee, Praihirunyakit, Pairoa, Gerschenson, Mariana, Phanuphak, Praphan, Valcour, Victor, Kim, Jerome H., Cecilia, Shikumaon
Format: Artigo
Język:Inglês
Wydane: 2012
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Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3715552/
https://ncbi.nlm.nih.gov/pubmed/23220732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3851/IMP2497
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