Feedback Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase in Livers of Mice Treated with Mevinolin, a Competitive Inhibitor of the Reductase

Compactin (ML-236B) and the related compound, mevinolin, are competitive inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG CoA reductase), the rate-controlling enzyme in cholesterol synthesis. Previous studies have shown that administration of compactin to cultured cells elicits a c...

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Pubblicato in:	J Clin Invest
Autori principali:	Kita, Toru, Brown, Michael S., Goldstein, Joseph L.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1980
Soggetti:	Articles
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC371547/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6903572/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI109938
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