Epac activation, altered calcium homeostasis and ventricular arrhythmogenesis in the murine heart

The recently described exchange protein directly activated by cAMP (Epac) has been implicated in distinct protein kinase A-independent cellular signalling pathways. We investigated the role of Epac activation in adrenergically mediated ventricular arrhythmogenesis. In contrast to observations in con...

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Bibliographic Details
Main Authors: Hothi, Sandeep S., Gurung, Iman S., Heathcote, Jennifer C., Zhang, Yanmin, Booth, Stephen W., Skepper, Jeremy N., Grace, Andrew A., Huang, Christopher L.-H.
Format: Artigo
Language:Inglês
Published: Springer-Verlag 2008
Subjects:
Cardiovascular Physiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3714550/
https://ncbi.nlm.nih.gov/pubmed/18600344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-008-0508-3
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