Blockade of IL-1R signaling diminishes Paneth cell depletion and Toxoplasma gondii induced ileitis in mice

Interleukin 1 is a critical inflammatory mediator and involved in host defense to several pathogens. Oral T. gondii infection causes lethal ileitis in C57BL/6 (BL6) mice and serves to investigate the mechanisms of acute intestinal inflammation. Here we show that IL-1 is expressed upon oral T. gondii...

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Bibliographische Detailangaben
Hauptverfasser: Villeret, Bérengère, Brault, Léa, Couturier-Maillard, Aurélie, Robinet, Pauline, Vasseur, Virginie, Secher, Thomas, Dimier-Poisson, Isabelle, Jacobs, Muazzam, Zheng, Song-Guo, Quesniaux, Valérie F, Ryffel, Bernhard
Format: Artigo
Sprache:Inglês
Veröffentlicht: e-Century Publishing Corporation 2013
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3714202/
https://ncbi.nlm.nih.gov/pubmed/23885328
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