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Ran GTPase promotes oocyte polarization by regulating ERM (Ezrin/Radixin/Moesin) inactivation

Asymmetric meiotic divisions in mammalian oocytes are driven by the eccentric positioning of the spindle, along with a dramatic reorganization of the overlying cortex, including a loss of microvilli and formation of a thick actin cap. Actin polarization relies on a Ran-GTP gradient centered on metap...

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Detalhes bibliográficos
Main Authors: Dehapiot, Benoit, Halet, Guillaume
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3713125/
https://ncbi.nlm.nih.gov/pubmed/23656777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.24901
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