Selective Inhibition by Ethanol of Mitochondrial Calcium Influx Mediated by Uncoupling Protein-2 in Relation to N-Methyl-D-Aspartate Cytotoxicity in Cultured Neurons

BACKGROUND: We have shown the involvement of mitochondrial uncoupling protein-2 (UCP2) in the cytotoxicity by N-methyl-D-aspartate receptor (NMDAR) through a mechanism relevant to the increased mitochondrial Ca(2+) levels in HEK293 cells with acquired NMDAR channels. Here, we evaluated pharmacologic...

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Detalhes bibliográficos
Main Authors: Fukumori, Ryo, Takarada, Takeshi, Nakazato, Ryota, Fujikawa, Koichi, Kou, Miki, Hinoi, Eiichi, Yoneda, Yukio
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3713054/
https://ncbi.nlm.nih.gov/pubmed/23874988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069718
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