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Axonal mRNA translation: an unexpected link to axon survival and the mitochondrion
Localized mRNA translation plays roles in dendrites and axons, but the regulatory mechanisms and downstream pathways are not well understood. Yoon et al. show that lamin B2, well known as a nuclear protein, undergoes regulated synthesis in axons, promoting mitochondrial function and axon survival.
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3712866/ https://ncbi.nlm.nih.gov/pubmed/22365539 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2012.02.005 |
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