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Use of Phage Display to Generate Conformation-Sensor Recombinant Antibodies

We describe a phage display approach that we have previously used to generate conformation-sensor antibodies that recognize specifically and stabilize the oxidized, inactive conformation of protein tyrosine phosphatase 1B (PTP1B). We use a solution-based panning and screening strategy conducted in t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Haque, Aftabul, Tonks, Nicholas K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712638/
https://ncbi.nlm.nih.gov/pubmed/23154784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nprot.2012.132
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