DNA-intercalators Causing Rapid Re-expression of Methylated and Silenced Genes in Cancer Cells

Epigenetic inactivation of tumor-suppressor and other regulatory genes plays a critical role in carcinogenesis. Transcriptional silencing is often maintained by DNA methyl transferase (DNMT)-mediated hypermethylation of CpG islands in promoter DNA. Nucleoside analogs including azacytidine and decita...

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Main Authors: Hossain, M. Zulfiquer, Healey, Megan A., Lee, Calvin, Poh, Weijie, Yerram, Sashidhar R., Patel, Kalpesh, Azad, Nilofer S., Herman, James G., Kern, Scott E.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712575/
https://ncbi.nlm.nih.gov/pubmed/23593653
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