From Single Nucleotide Polymorphism to Transcriptional Mechanism: A Model for FRMD3 in Diabetic Nephropathy

Genome-wide association studies have proven to be highly effective at defining relationships between single nucleotide polymorphisms (SNPs) and clinical phenotypes in complex diseases. Establishing a mechanistic link between a noncoding SNP and the clinical outcome is a significant hurdle in transla...

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Autors principals: Martini, Sebastian, Nair, Viji, Patel, Sanjeevkumar R., Eichinger, Felix, Nelson, Robert G., Weil, E. Jennifer, Pezzolesi, Marcus G., Krolewski, Andrzej S., Randolph, Ann, Keller, Benjamin J., Werner, Thomas, Kretzler, Matthias
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2013
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712052/
https://ncbi.nlm.nih.gov/pubmed/23434934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-1416
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