The α5 Subunit Regulates the Expression and Function of α4*-Containing Neuronal Nicotinic Acetylcholine Receptors in the Ventral-Tegmental Area

Human genetic association studies have shown gene variants in the α5 subunit of the neuronal nicotinic receptor (nAChR) influence both ethanol and nicotine dependence. The α5 subunit is an accessory subunit that facilitates α4* nAChRs assembly in vitro. However, it is unknown whether this occurs in...

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Autors principals: Chatterjee, Susmita, Santos, Nathan, Holgate, Joan, Haass-Koffler, Carolina L., Hopf, F. Woodward, Kharazia, Viktor, Lester, Henry, Bonci, Antonello, Bartlett, Selena E.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712017/
https://ncbi.nlm.nih.gov/pubmed/23869214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0068300
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