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New drug classes for the treatment of partial onset epilepsy: focus on perampanel

Perampanel (2-[2-oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl] benzonitrile hydrate) is the latest in the line of new antiepileptic drugs with a novel mechanism of action. Perampanel inhibits α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA)-induced increases in intracellular Ca(2+...

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Bibliografiske detaljer
Main Authors: Shih, Jerry J, Tatum, William O, Rudzinski, Leslie A
Format: Artigo
Sprog:Inglês
Udgivet: Dove Medical Press 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711947/
https://ncbi.nlm.nih.gov/pubmed/23874099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/TCRM.S37317
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