Rheb Activation in Subventricular Zone Progenitors Leads to Heterotopia, Ectopic Neuronal Differentiation, and Rapamycin-Sensitive Olfactory Micronodules and Dendrite Hypertrophy of Newborn Neurons

Mammalian target of rapamycin (mTOR) hyperactivity in perinatal neural progenitor cells (NPCs) of tuberous sclerosis complex 1 (Tsc1) heterozygote mice leads to heterotopia and abnormal neuronal morphogenesis as seen in patients with tuberous sclerosis. Considering that pathological hyperactive mTOR...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Lafourcade, Carlos A., Lin, Tiffany V., Feliciano, David M., Zhang, Longbo, Hsieh, Lawrence S., Bordey, Angélique
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Society for Neuroscience 2013
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711634/
https://ncbi.nlm.nih.gov/pubmed/23392671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1840-12.2013
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