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Isolation of α(L) I domain mutants mediating firm cell adhesion using a novel flow-based sorting method

The inserted (I) domain of α(L)β(2) integrin (LFA-1) contains the entire binding site of the molecule. It mediates both rolling and firm adhesion of leukocytes at sites of inflammation depending on the activation state of the integrin. The affinity change of the entire integrin can be mimicked by th...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Pepper, Lauren R., Parthasarathy, Ranganath, Robbins, Gregory P., Dang, Nicholas N., Hammer, Daniel A., Boder, Eric T.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2013
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711393/
https://ncbi.nlm.nih.gov/pubmed/23788664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzt028
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