Two Salt Bridges Differentially Contribute to the Maintenance of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channel Function

Previous studies have identified two salt bridges in human CFTR chloride ion channels, Arg(352)-Asp(993) and Arg(347)-Asp(924), that are required for normal channel function. In the present study, we determined how the two salt bridges cooperate to maintain the open pore architecture of CFTR. Our da...

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Main Authors: Cui, Guiying, Freeman, Cody S., Knotts, Taylor, Prince, Chengyu Z., Kuang, Christopher, McCarty, Nael A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Cell Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711338/
https://ncbi.nlm.nih.gov/pubmed/23709221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.476226
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