Structural Characterization of Carbohydrate Binding by LMAN1 Protein Provides New Insight into the Endoplasmic Reticulum Export of Factors V (FV) and VIII (FVIII)

LMAN1 (ERGIC-53) is a key mammalian cargo receptor responsible for the export of a subset of glycoproteins from the endoplasmic reticulum. Together with its soluble coreceptor MCFD2, LMAN1 transports coagulation factors V (FV) and VIII (FVIII). Mutations in LMAN1 or MCFD2 cause the genetic bleeding...

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Dettagli Bibliografici
Autori principali: Zheng, Chunlei, Page, Richard C., Das, Vaijayanti, Nix, Jay C., Wigren, Edvard, Misra, Saurav, Zhang, Bin
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711315/
https://ncbi.nlm.nih.gov/pubmed/23709226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.461434
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