Dysregulated TLR3-Dependent Signaling and Innate Immune Activation in Superoxide-Deficient Macrophages From Non-Obese Diabetic Mice

In Type 1 diabetes (T1D), reactive oxygen species (ROS) and pro-inflammatory cytokines produced by macrophages and other innate immune cells destroy pancreatic β-cells while promoting autoreactive T cell maturation. Superoxide-deficient Non-Obese Diabetic mice (NOD.Ncf1(m1J)) are resistant to sponta...

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Détails bibliographiques
Auteurs principaux: Seleme, Maria C., Lei, Weiqi, Burg, Ashley R., Goh, Kah Yong, Metz, Allison, Steele, Chad, Tse, Hubert M.
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711256/
https://ncbi.nlm.nih.gov/pubmed/22361747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2012.01.027
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