GENETIC MODIFIERS OF LIVER DISEASE IN CYSTIC FIBROSIS

CONTEXT: A subset (~3–5%) of patients with cystic fibrosis (CF) develops severe liver disease (CFLD) with portal hypertension. OBJECTIVE: To assess whether any of 9 polymorphisms in 5 candidate genes (SERPINA1, ACE, GSTP1, MBL2, and TGFB1) are associated with severe liver disease in CF patients. DES...

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Auteurs principaux: Bartlett, Jaclyn R., Friedman, Kenneth J., Ling, Simon C., Pace, Rhonda G., Bell, Scott C., Bourke, Billy, Castaldo, Giuseppe, Castellani, Carlo, Cipolli, Marco, Colombo, Carla, Colombo, John L., Debray, Dominique, Fernandez, Adriana, Lacaille, Florence, Macek, Milan, Rowland, Marion, Salvatore, Francesco, Taylor, Christopher J., Wainwright, Claire, Wilschanski, Michael, Zemková, Dana, Hannah, William B., Phillips, M. James, Corey, Mary, Zielenski, Julian, Dorfman, Ruslan, Wang, Yunfei, Zou, Fei, Silverman, Lawrence M., Drumm, Mitchell L., Wright, Fred A., Lange, Ethan M., Durie, Peter R., Knowles, Michael R.
Format: Artigo
Langue:Inglês
Publié: 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711243/
https://ncbi.nlm.nih.gov/pubmed/19738092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2009.1295
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