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Increasing Tip60 HAT Levels Rescues Axonal Transport Defects and Associated Behavioral Phenotypes in a Drosophila Alzheimer's Disease Model

Axonal transport defects and axonopathy are prominent in early preclinical stages of Alzheimer's disease (AD), often preceding known disease-related pathology by over a year. As epigenetic transcriptional regulatory mechanisms, such as histone acetylation, are critical for neurogenesis, it is p...

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Main Authors: Johnson, Ashley A., Sarthi, Jessica, Pirooznia, Sheila K., Reube, William, Elefant, Felice
格式: Artigo
語言:Inglês
出版: Society for Neuroscience 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711104/
https://ncbi.nlm.nih.gov/pubmed/23616558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3739-12.2013
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